This report presents the results of the project Safe Future Inland Transport Systems (SafeFITS), which aims to develop a robust road safety decision-making tool to support the most appropriate road safety policies and measures to achieve tangible results. Road accidents constitute a major social problem in modern societies, accounting for more than 1 million accidents per year in EU-28 (2,900 per day), resulting in 1.4 million injuries and 26,000 fatalities (70 per day) (WHO, 2015). Road traffic injuries are estimated to be the eighth leading cause of death globally, and more than half of the people killed in traffic accidents are young adults aged between 15 and 44 years. In low-income and middle-income countries, the rates of road traffic injuries are twice those in high-income countries and still increasing. This can be partly attributed to rapid motorization in many developing countries, without any investment being made in road safety. Current trends suggest that, unless action is taken, traffic injuries will become the fifth leading cause of death by 2030, with the disparity between high-income and low-income countries further increased.